New bis-quinolinium chiral ionic liquids (CILs) were synthesized in good yields starting from isomannide and isosorbide by a straightforward procedure that maintains the absolute stereostructure of the isohexide scaffolds. Thermal gravimetric analysis and differential scanning calorimetry, aimed at investigating the short thermal stability and the thermal behaviour of the synthesized ionic compounds are presented.
We present a fluorescent pH biosensor based on a conjugated coumarin-triazine scaffold that is excitable in the visible range, shows pseudo-linear ratiometric response over more than 6 pH units with a single fluorogenic unit, and allows imaging of the whole endo-lysosomal pH landscape of living cells with a single acquisition. The probe can discriminate, on the basis of intracellular acidity, between physiologic and tumor cells, being potentially suitable in perspective as diagnostic tool.
New article just published by the Smart Polymer Group: "Mechanochromic LLDPE Films Doped with NIR Reflective Paliogen Black" (C. Micheletti, P. Minei, Prof. G. Ruggeri, Prof. A. Pucci). The work shows the self-diagnostic properties of P-black/LLDPE film as a new solution to detect deformations through optical and thermal outputs.
Here the abstract of the article.
The perylene bisimide derivative Paliogen Black (P-black) is proposed as a new chromogenic probe that shows visible (Vis) and near-infrared (NIR) responses after mechanical solicitations of host linear low-density polyethylene (LLDPE) films.
Congratulations to our Ph.D. students Andrea Bonini, Noemi Poma and Federico Vivaldi from the Chemistry Lab for Analytical Technologies and Sensors (CATS), for their recent review entitled "Advances in biosensing: The CRISPR/Cas system as a new powerful tool for the detection of nucleic acids". This year, the Nobel Prize in Chemistry was awarded for the use of the CRISPR/Cas system in molecular biology. Recently, the coupling of the CRISPR/Cas system with isothermal amplification methods is fostering the development of innovative optical and electrochemical Point of Care (POC) devices and seems to offer unprecedented possibilities.
