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Uscito il bando Dottorati PON tematiche green

Uscito il bando Dottorati PON tematiche green

E' stato pubblicato il bando per l'assegnazione di borse aggiuntive di Dottorato su tematiche green a valere sui fondi PON 2014-2020. Al Dottorato in Scienze Chimiche e dei Materiali sono...

Bando PRIMULE@DSCM per dottorandi/e

Bando PRIMULE@DSCM per dottorandi/e

E' stato pubblicato sull'albo ufficiale di ateneo il Bando PRIMULE@DSCM. Il bando, riservato a allievi/e di Dottorato in corso, è volto a finanziare progetti di ricerca di 1 anno da...

 

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enantioselective organozincStabilised arylzinc iodide, prepared by direct insertion of zinc into aryl iodides, were used as nucleophiles in the Hayashi Rh‐catalysed enantioselective conjugate addition to enones. The reaction conditions were optimized in the addition of phenylzinc iodide to 2‐cyclohexen‐1‐one, obtaining good yields and 99% ee of the addition product. The general applicability of the protocol was checked using different arylzinc iodides and enones. Organometallic reagents endowed with both halogen and electrophilic groups were also successfully used.

protein fluorescence ligandsProtein binding heavily modulates drug activity. Therefore, the binding features need to be elucidated when chemistry researchers study new molecules to be used as drugs. This short review concerns the analysis of the binding of small molecules to a fluorescent protein (the golden standard serum albumin) by using direct fluorescence titrations. This widely used technique is valuable, but often much more tricky than it might appear at first sight. We aim to share a mechanistic approach, discussing the critical aspects for correctly designing the experiments and treating the data.

gold silver biomoleculesCongratulations to our Ph.D. student Francesca Binacchi for her recent scientific pubblication entitled: "On the Different Mode of Action of Au(I)/Ag(I)-NHC Bis-Anthracenyl Complexes Towards Selected Target Biomolecules" Gold and silver N-heterocyclic carbenes (NHCs) are emerging for therapeutic applications. Multiple techniques are here used to unveil the mechanistic details of the binding to different biosubstrates of bis(1-(anthracen-9-ylmethyl)-3-ethylimidazol-2-ylidene) silver chloride [Ag(EIA)2]Cl and bis(1-(anthracen-9-ylmethyl)-3-ethylimidazol-2-ylidene) gold chloride [Au(EIA)2]Cl.

cell polymer interactionsCongratulations to our Ph.D. students Simona Braccini and Gianni Pecorini for their scientific publication entitled “Adhesion of fibroblast cells on thin films representing surfaces of polymeric scaffolds of human urethra rationalized by molecular models of integrin binding: cell adhesion on polymeric scaffolds for regenerative medicine” in the journal “Journal of Biotechnology”.

reactions using ppmAn inexpensive and new triphenylphosphine‐based palladacycle has been developed as a pre‐catalyst leading to highly effective Stille cross coupling reactions in water under mild conditions. Only 500‐1000 ppm of Pd suffices for couplings involving a variety of aryl/heteroaryl halides with aryl/hetaryl stannanes. Several drug intermediates can be prepared using this catalyst in aqueous nanoreactors formed by 2 wt % Brij‐30 in water.

exploiting isohexide scaffoldsNew bis-quinolinium chiral ionic liquids (CILs) were synthesized in good yields starting from isomannide and isosorbide by a straightforward procedure that maintains the absolute stereostructure of the isohexide scaffolds. Thermal gravimetric analysis and differential scanning calorimetry, aimed at investigating the short thermal stability and the thermal behaviour of the synthesized ionic compounds are presented.

DCCI|UNIPI
Dipartimento di Chimica
e Chimica Industriale
Department of Chemistry

and Industrial Chemistry
Via G. Moruzzi, 13 - Pisa, Italy
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Corso di Dottorato in
Scienze Chimiche e dei Materiali
Doctoral School in Chemistry
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