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Dr. Dario Puppi

Title of the PhD project:
Biotechnological polymers for advances technologies and applications

Abstract of the PhD project:
Due to increasing concerns on environmental problems and limited fossil resources, biobased production of monomers and polymers through industrial biotechnologies based on microbial fermentation is attracting growing attention. Biotechnological polymers have assumed great interest in many common applications, but they still show several drawbacks mainly related to their processing. This is particularly true when material processing is intended to be approached by advanced technologies based on Additive manufacturing (AM) that represent one of the key-elements of Industry 4.0. The aim of this work is to provide a systematic investigation for the physical/chemical modifications of biotechnological polymers and oligomers to obtain new bio-based materials suitable to be reproducibly processed by AM techniques. The developed materials will be finely tuned and optimized to be employed with Fused Deposition Modelling (FDM) and Computer-Aided Wet-Spinning (CAWS) AM techniques for the manufacturing of items/devices for advanced biomedical, environmental and cosmetics applications.

• Puppi D., Pecorini G., Chiellini F., Biomedical Processing of Polyhydroxyalkanoates, Bioengineering, 2019, 6(4), 108,
• Braccini S., Pecorini G., Chiellini F., Bakos D., Miertus S., Frecer V., Adhesion of fibroblast cells on thin films representing surfaces of polymeric scaffolds of human urethra rationalized by molecular models of integrin binding cell adhesion on polymeric scaffolds for regenerative medicine, Journal of Biotechnology, 2020, 324, 233-238.
• Pecorini G., Chiellini F., Puppi D., Mechanical Characterization of Additive Manufactured Polymeric Scaffolds for Tissue Engineering, in Biomimetic Biomaterials for Bone Tissue Regeneration, Editor Dash Mamoni, Publisher Springer Singapore, Year 2022,

Oral communications at conferences:
• Pecorini G., Braccini S., Chiellini F., Puppi D., Additive manufacturing of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-based composites for bone tissue regeneration, XIII Convegno Nazionale INSTM, January 23-26, 2022

Poster communications at conferences:
• Pecorini G., Braccini S., Puppi D., Chiellini F., Development of new Scaffolds based on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and Poly(D,L-lactide-co-glycolide) for Bone Tissue Regeneration, Virtual Milan Polymer Days Congress, 15-17 July 2020.
• Pecorini G., Braccini S., Simoni S., Martinelli E., Carmassi L., Li Vecchi D., Chiellini F., Puppi D., Additive Manufacturing of Biotechnological Polymers and Relevant Composites for Biomedical Applications, Chemistry for the Future, June 30 – July 02, 2021
• Pecorini G., Braccini S., Chiellini F., Puppi D., Additive Manufacturing of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/Poly(D,L-lactide-co-glycolide) Biphasic Scaffolds for Bone Tissue Regeneration, TERMIS 6th World Congress, November 15-19, 2021

Other achievements:


Dipartimento di Chimica e Chimica Industriale
Department of Chemistry and Industrial Chemistry
Via G. Moruzzi, 13 - Pisa, Italy
Corso di Dottorato in Scienze Chimiche e dei Materiali
Doctoral School in Chemistry and Material Science
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