Cycle / Years
41^th cycle [2025-2028]

Contacts
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Supervisor(s)
Dott.ssa Marialaura Dilillo, Prof.ssa Ilaria Degano

Title of the PhD project
Development of analytical methods for the physicochemical characterization of therapeutic formulations

Abstract of the PhD project
This PhD project aims to develop advanced analytical strategies for the characterization of therapeutic plasma proteins intended for rare disease treatment. Current therapies based on fresh frozen plasma present limitations, including safety risks, variability, and supply dependence. The research focuses on isolating and profiling clinically relevant proteins such as ceruloplasmin and coagulation factor V, emphasizing the identification of active isoforms and detection of aggregates that may affect efficacy and safety. Techniques including Field-Flow Fractionation, UPLC-UV/MS, and capillary electrophoresis will be optimized and validated through rigorous assessment of selectivity, sensitivity, recovery, and matrix effects. The final goal is to establish reliable, cost-effective quality control protocols suitable for industrial pharmaceutical development.

Academic Fields and Disciplines (SSD), main and secondary
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Educational and third mission activities
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International
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Funding
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