Stabilized Arylzinc Iodides in Negishi Acylative Cross-Coupling: A Modular Synthesis of Chalcones.
Stabilized arylzinc iodides, synthesized by direct insertion of zinc into the corresponding halides, were used as nucleophiles into an acylative Negishi coupling reaction to synthesize chalcones. The reaction conditions were optimized to afford optimal results on a model reaction and then applied to synthesize nine compounds. Esters, chlorides, electron-rich, electron-poor and sterically hindered substrates are well tolerated and even heteroaryl derivatives can be synthesized.
Lipomyces starkeyi: una cell factory per la produzione di biodiesel di nuova generazione da canne giganti infestanti. Quarto appuntamento con il nuovo progetto DSCM di comunicazione della scienza nato dalla collaborazione con Microbiologia Italia. L’articolo divulgativo del mese di aprile è stato realizzato e curato dal Dott. Nicola Di Fidio. La transizione da un’economia basata sulle risorse fossili ad una bioeconomia è un obiettivo globale attuale volto a contrastare alcune importanti problematiche, come i cambiamenti climatici e l’inquinamento ambientale; e per ridurre la dipendenza delle attività antropiche dalle fonti fossili.
Congratulations to our Ph.D. student Gianni Pecorini for his book chapter entitled “Mechanical Characterization of Additive Manufactured Polymeric Scaffolds for Tissue Engineering" in the book entitled "Biomimetic Biomaterials forTissue Regeneration and Drug Delivery". In the last decades, tissue engineering has become a promising and important field of research that is opening new perspectives for the treatment of tissue diseases or injuries.
Congratulations to our Ph.D. student Alberto Gobbo for his scientific publication entitled “A Green Synthesis of Carbene-Metal-Amides (CMAs) and Carboline-Derived CMAs with Potent in Vitro and ex Vivo Anticancer Activity” in ChemMedChem. The synthesis of Carbene-Metal-Amide (CMA) complexes based on the coinage metals (Au, Ag, Cu) and N-heterocyclic carbenes (NHCs) as ancillary ligands is improved by circumventing the use of toxic organic solvents which were previously required for their purification.