Here we present this review work, based on a scrupulous and important bibliographic reaserch concerning glycoconjugated metal complexes used for tumor therapy and diagnosis.
Tumor cells display augmented requests for carbohydrates and, in particular, for glucose in order to sustain their high proliferation rate, which causes an increased glycolytic process (Warburg effect).
Since several metal complexes display diagnostic and/or therapeutic properties, their conjugation to carbohydrate portions often induce their preferential accumulation in cancer cells. For this reason, the lack of selective cytotoxicity displayed by several metal‐based chemotherapeutic agents, may also be solved by the conjugation of these agents to carbohydrate moieties.
The work is available at the following link: https://doi.org/10.1002/cmdc.202000456
