The information on this page refers to the period of PhD and post-doc (last update: August 2022)
For information updated see the website: https://ricerca.dcci.unipi.it/pelosi-chiara.html
Contacts:
https://orcid.org/0000-0001-5824-4372 - Scopus Author ID: 57203892116
Projects:
I am currently enrolled as a post-doc researcher in the project Materiali di nuova generazione per il restauro di beni culturali: nuovo approccio alla fruizione di AGM for CuHe: Advanced Green Materials for Cultural Heritage.
My research involves the use of calorimetric techniques for the evaluation of several matrices, as protein-polymer conjugates with biomedical applications, new generation materials for cultural heritages, composite materials made by synthetic or natural polymers and animal extracted fibers, deep-eutectic solvents. We investigate also the interaction among new Pt anticancer complexes and proteins.
In a previous moment, during my PhD I have worked in collaboration with Pr. Frederik Wurm (MESA+ Institute for Nanotechnology Universiteit Twente, Enschede, NL) on the critical design, synthesis, characterization and biochemical evaluation of novel protein-polymer conjugates, based on poly(phosphoester)s, a promising class of polymer, potential alternative for poly(ethylene glycol) (PEG) (the most common polymer used in the bioconjugation field). A wide set of conjugates was synthesized, their activity and thermal stability was evaluated using Nano-Differential Scanning Calorimetry, Nano-Differential Scanning Fluorimetry and circular dichroism. The biodegradability and biocompatibility of the samples in simulated human fluids was tested. In addition, a biophysical evaluation of the conjugates dynamics in the dry form was performed by neutron scattering spectroscopy and differential scanning calorimetry.
Publications:
Unfreezing of molecular motions in protein-polymer conjugates: a calorimetric study. Pelosi, C.*; Tombari, E.; Wurm, F.; Tinè, M.R. (*: first author and corresponding author) Journal of Thermal Analysis and Calorimetry, 2022, doi:10.1007/s10973-022-11437-x
A circular dichroism study of the protective role of polyphosphoesters (PPE) polymer chains in PPE-myoglobin conjugates. Pelosi, C*; Arrico, L.; Zinna, F.; Wurm, F.; Di Bari, L., Tinè, M.R. (*: first author and co-corresponding author), Chirality, 2022, 1-9. https://doi.org/10.1002/chir.23486
Blood compatibility of hydrophilic polyphosphoesters. Pelosi, C.; Constantinescu, I.; Son, H.; Tine, M.R.; Kizhakkedathu, J.; Wurm, F., ACS Applied Bio Materials, 2022, 5(3), 1151–1158. https://doi.org/10.1021/acsabm.1c01210
Valorization of not soluble byproducts deriving from green keratin extraction from poultry feathers as filler for biocomposites. Pulidori, E.; Micalizzi, S.; Bramanti, E.; Bernazzani, L.; De Maria, C.; Pelosi, C.*; Tinè, M.R.; Vozzi, G.; Duce, C. (*: co-corresponding author), Journal of Thermal Analysis and Calorimetry, 2022, 147(9), 5377-5390 https://doi.org/10.1007/s10973-021-11166-7
Amphiphilic Polyphosphonate Copolymers as New Additives for PDMS-Based Antifouling Coatings. Guazzelli, E.; Lusiani, N.; Monni, G.; Oliva, M.; Pelosi, C.; Wurm, F.R.; Pretti, C.; Martinelli, E. Polymers 2021, 13(19), 3414. https://doi.org/10.3390/polym13193414
One-pot process: Microwave-assisted keratin extraction and direct electrospinning to obtain keratin-based bioplastic. Pulidori, E., Micalizzi, S., Bramanti, E., Bernazzani, L., Duce, C., De Maria, C., Montemurro, F., Pelosi, C., De Acutis, A., Vozzi G, Tinè, M.R. International Journal of Molecular Science, MDPI, 2021, 22(17), 9597 https://doi.org/10.3390/ijms22179597
The effect of polymer hydrophilicity and molar mass on the properties of the protein in protein-polymer conjugates: the case of PPE-ylated myoglobin. Pelosi, C., Duce, C., Tinè, M.R., Wurm, F.R. Biomacromolecules, Elsevier, 2021, 22(5), 1932-1943 https://doi.org/10.1021/acs.biomac.1c00058
Thermodynamic Evaluation of the Interactions between Anticancer Pt(II) Complexes and Model Proteins. Pelosi, C.; Saitta, F.; Zerino, C.; Canil, G.; Biver, T.; Pratesi, A.; Duce, C.; Fessas, D.; Gabbiani, C.; Tiné, M.R. Molecules, MDPI, 2021, 26 (8), 2376. https://doi.org/10.3390/molecules26082376
Investigation of the LCST-Thermoresponsive Behavior of Novel Oligo(Ethylene Glycol)-Modified Pentafluorostyrene Homopolymers Pelosi, C., Guazzelli, E., Calosi, M., Bernazzani, L., Tinè, M.R., Duce, C., Martinelli, E. Applied Science, MDPI, 2021, 11, 2771. https://doi.org/10.3390/app11062711
Main-chain water-soluble polyphosphoesters: multi-functional polymers as degradable PEG-alternatives for biomedical applications. Pelosi C., Tinè M. R., Wurm F. European Polymer Journal, Elsevier, 2020, 141, 110079. https://doi.org/10.1016/j.eurpolymj.2020.110079
DSC on ovalbumin-hematite “tempera” paints: the role of water and pigment on protein stability. Saitta F., Signorelli M., Bramanti E., Pizzimenti S., Pelosi C., Duce C., Fessas D., Bonaduce I., Tinè M. R. Thermochimica Acta, Elsevier, 2020, 694, 178780. https://doi.org/10.1016/j.tca.2020.178780
Insight into Protein–Polymer Conjugate Relaxation Dynamics: The Importance of Polymer Grafting. Russo D., Pelosi C., Wurm F., Frick B., Ollivier J., Teixeira J. Macromolecular Bioscience, Wiley, 2020, 20 (6), 1900410. https://doi.org/10.1002/mabi.201900410
Thermodynamic stability of myoglobin-poly(ethylene glycol) bioconjugates: A calorimetric study. Pelosi C.*, Saitta F.*, Wurm F., Fessas D., Tinè M. R., Duce C. (*: first co-authors) Thermochimica Acta, Elsevier, 2019, 671, 26-31 https://doi.org/10.1016/j.tca.2018.11.001
PPEylation of proteins: Synthesis, activity, and stability of myoglobin-polyphosphoester conjugates. Pelosi C., Duce C., Russo D., Tinè M. R., Wurm F. European Polymer Journal, Elsevier, 2018, 108, 357-363 https://doi.org/10.1016/j.eurpolymj.2018.09.019
Awards:
Lucci Award 2022
It is a prestigious prize given by the Italian Association on Thermal Analysis and Calorimetry (AICAT) to honor the memory of Prof. Alberto Lucci. The prize is given to a young Italian researcher who contributed significantly to the field of thermal analysis and calorimetry. Dr Chiara Pelosi will receive the prize in occasion of the conference ESTAC13 (Palermo, 19-22/09/22), where she will hold an awarded plenary lecture on her research.
II edition INSTM/Polymer Award. Ex-equo special prize for the video quality and the communication skills
The prize, sponsored by the INSTM consortium and the open access journal Polymer, has the aim to give value to the research of young researchers, rewarding on of their publications in the filed of polymers and/or composites. The video, with which Dr Pelosi won the prize, is available at the following link:
https://www.instm.it/news/2_premio_instm_polymers_ecco_tuttii_vincitori.aspx
