chemo enzymatic isosorbideA new chemoenzymatic protocol for the preparation of 6-aminoisomannide was developed starting from renewable sources. The key step of the protocol was a biocatalysed highly regioselective acetylation of the 3-endo hydroxyl group of isosorbide, performed employing Immobilized Amano Lipase PS onto octadecyl methacrylate resin. The catalyst gave good results even on a large scale (10mmol) and it could be recycled 3 times without loss of selectivity.

The full paper is available at:
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1532-5825

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DCCI|UNIPI
Dipartimento di Chimica e Chimica Industriale
Department of Chemistry and Industrial Chemistry
Via G. Moruzzi, 13 - Pisa, Italy
DSCM
Corso di Dottorato in Scienze Chimiche e dei Materiali
Doctoral School in Chemistry and Material Science
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