Cycle/Years
39th cycle [2023-2026]
Contacts
https://twitter.com/c_aterinac
https://www.linkedin.com/in/caterina-campinoti/
Supervisors
Prof. Marco Lessi, Dr. Antonio Del Vecchio
Title of the PhD project
Sustainable Approaches for the Synthesis and Functionalization of Heterocycles
Abstract of the PhD project
The synthesis and functionalization of heterocycles is a continually expanding research field of organic chemistry, playing a pivotal role for the preparation of key structures in many biologically active compounds and functional materials. Over the past decades, the demand for novel and more efficient synthetic methodologies has been coupled with the necessity to adopt more sustainable approaches, aiming to minimize waste generation and environmental impact. Within this context, the application of electrochemistry to organic synthesis has emerged as a particularly intriguing strategy, representing an environmentally-benign alternative to conventional redox protocols and for the development of new radical-based transformations. On the other hand, mechanochemistry provides a novel approach to perform reactions, reducing dramatically the reaction time and the employ of toxic solvents. These techniques offer sustainable alternatives to traditional benchmark organic syntheses, having the potential to reveal, at the same time, unexplored reaction pathways for the discovery of new reactivities.
This PhD project will focus on the investigation of sustainable approaches for the synthesis and functionalization of heterocycles. Specifically, oxidative transformations will be targeted via electrochemical approaches, while mechanochemistry will be exploited for the investigation of redox-neutral and reductive reaction pathways. Special emphasis will be placed on C-H activation reactions to achieve regioselective formation of new C-C and C-heteroatom bonds.
Academic Fields and Disciplines (SSD)
CHIM06
Publications
• Campinoti, C.; Taddeucci, A.; Sardelli, F.; Pescitelli, G., Di Bari, L.; Lessi, M.; Zinna, F; Strong chiroptical properties from thin films of chiral imidazole derivatives allowing for easy detection of circularly polarized luminescence, J. Mater. Chem. C 2024, 12, 9210-9216
Oral communications at conferences
• Campinoti, C.; Sardelli, F.; Bellina, F.; Di Bari, L.; Lessi, M.; Zinna, F.; “Novel Azole-based Chromophores for Optoelectronic Applications”, CINMPIS Days, 7-9 February 2024, Bari (Italy)
• Campinoti, C.; Sardelli, F; Pineschi, M.; Di Francesco, F.; Vivaldi, F.M.; Bellina, F.; Lessi, M.; Del Vecchio, A.; “Electro-oxidative nitroso-Diels-Alder reaction for the regioselective functionalization of dihydropyridines”, CFF – Chemistry for the Future, 3-5 July 2024, Pisa (Italy)
• Campinoti, C.; Taddeucci, A., Sardelli, F.; Pescitelli, G.; Di Bari, L.; Lessi, M.; Zinna, F.; “Novel Azole-based Chromophores for Optoelectronic Applications”, XXVIII Congresso Nazionale della Società Chimica Italiana, 26-30 August 2024, Milano (Italy)
Poster communications at conferences
• Campinoti, C.; Sardelli, F.; Bellina, F.; Di Bari, L.; Lessi, M.; Zinna, F.; “Novel Azole-based Chromophores for Optoelectronic Applications”, CFF - Chemistry for the Future, 28-30 June 2023, Pisa (Italy)
• Campinoti, C.; Sardelli, F; Pineschi, M.; Di Francesco, F.; Vivaldi, F.M.; Bellina, F.; Lessi, M.; Del Vecchio, A.; “Electro-oxidative nitroso-Diels-Alder reaction for the regioselective functionalization of dihydropyridines”, CFF – Chemistry for the Future, 3-5 July 2024, Pisa (Italy)
Other achievements
• Best Poster Award, “Electro-oxidative nitroso-Diels-Alder reaction for the regioselective functionalization of dihydropyridines”, CFF – Chemistry for the Future, 3-5 July 2024, Pisa (Italy)
