Contacts:

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ResearchGate Profile: https://www.researchgate.net/profile/Andrea_Cesari
LinkedIn Profile: https://www.linkedin.com/in/andrea-cesari-106627130/
Orcid: https://orcid.org/0000-0002-9927-0953
Scopus Author ID: https://www.scopus.com/authid/detail.uri?authorId=57202906657

Supervisors:
Gloria Uccello Barretta

Title:
The role of NMR spectroscopy in understanding molecular recognition mechanisms

Abstract:
The use of low molecular weight or polymeric additives is becoming more and more popular in affecting the solubilizing power of cyclodextrins towards lipophilic drugs, the enantiodiscriminating efficiency of chiral auxiliaries for NMR spectroscopy and the final morphology of hybrid perovskites. A rational approach to these applications requires the comprehension of supramolecular aggregation processes at a molecular level by using spectroscopic methods.
The modification of chitosans represents a privileged way to the optimization of their mucoadhesive properties also in nanoparticulated systems dedicated to the development of controlled release platforms for lipophilic and hydrophilic drugs. Ascertaining the role of supramolecular aggregation of nanoaggregated forms on the final properties of the materials by non-empirical approaches represents a challenging task which can be realized by exploiting the great potentialities of NMR spectroscopy.

Publications:

A. Cesari, A. Fabiano, A. M. Piras, Y. Zambito, G. Uccello-Barretta, F. Balzano, Binding and mucoadhesion of sulfurated derivatives of quaternary ammonium-chitosans and their nanoaggregates: An NMR investigation, Journal of Pharmaceutical and Biomedical Analysis,177, 2020, 112852. doi: 10.1016/j.jpba.2019.112852

• R. Scarfiello, A. Cesari, D. Altamura, S. Masi, C. Nobile, F. Balzano, C. Giannini, V. Grillo, A. H. Tavabi, R. E. Dunin-Borkowski, G. Uccello-Barretta, P. D. Cozzoli, A. Rizzo, Mechanistic insight into the formation of colloidal WS2 nanoflakes in hot alkylamine media, Nanoscale Advances, 2019. doi: 10.1039/C9NA00279K

• Fabiano, A. M. Piras, G. Uccello-Barretta, F. Balzano, A. Cesari, L. Testai, V. Citi, Y. Zambito, Impact of mucoadhesive polymeric nanoparticulate systems on oral bioavailability of a macromolecular model drug, European Journal of Pharmaceutics and Biopharmaceutics, 130, 2018, 281-289. doi: 10.1016/j.ejpb.2018.07.010

Oral communications at congress:
...

Poster communications at congress:

• C. Micheletti, A. Cesari, A. Recchimurzo, I. Desideri, F. Balzano, G. Uccello-Barretta, NMR study of stability of Mitomycin-C formulations for ocular applications in the storage conditions, Chemistry for the Future - CFF 2019, Università di Pisa.

• A. Recchimurzo, A. Cesari, F. Balzano, Y. Zambito, G. Uccello-Barretta, Mucoadhesivity of thiolated ammonium-chitosans and their nanoaggregates by NMR spectroscopy, Chemistry for the Future - CFF 2019, Università di Pisa.

• C. Micheletti, A. Cesari, F. Balzano, G. Uccello-Barretta, Thiourea derivatives of amino alcohols: efficient chiral solvating agents for the differentiation of derivatives of amino acids by NMR spectroscopy, Chemistry for the Future - CFF 2019, Università di Pisa.

• A. Cesari, F. Balzano, G. Uccello-Barretta, Enantioselective inclusion processes of (+)- and (-)-oxazepam hemisuccinate into heptakis-(2,6-di-O-methyl)-β-cyclodextrin (DIMEB) and heptakis-(2,3,6-tri-O-methyl)-β-cyclodextrin (TRIMEB), 4^th International Summer School on Cyclodextrins 10 - 12 June 2019, Politecnico di Milano.

• C. Micheletti, R. Volpi, A. Cesari, F. Balzano, I. Desideri, G. Uccello-Barretta, Protective role of cyclodextrins against hydrolytic decomposition of bendamustine hydrochloride: an NMR investigation, 4th International Summer School on Cyclodextrins 10 - 12 June 2019, Politecnico di Milano.

• A. Recchimurzo, A. M. Piras, A. Cesari, F. Balzano, Y. Zambito, G. Uccello-Barretta, 2-Methyl-β-cyclodextrin conjugates of ammonium-chitosans: affinity towards Dalargin and protection against enzymatic hydrolysis, 4^th International Summer School on Cyclodextrins 10 - 12 June 2019, Politecnico di Milano.

• A.Cesari, F. Balzano, L. Basile, M. Pappalardo, C. Russotto, M. R. Lauro, S. Guccione, G. Uccello-Barretta, Inclusion mode of natural flavonoid Eriocitrin into β-cyclodextrin and (2-hydroxypropyl)-β-cyclodextrin: an NMR investigation, Chemistry for the Future - CFF 2018, Università di Pisa.